Application of Microwave-Assisted Drying to Shorten Granules Drying Process for the Preparation of Thunbergia laurifolia Lindl. Leaf Tablets

Thunbergia laurifolia Lindl. is a medicinal plant that belongs to the family of Acanthaceae. It possesses several biological and pharmacological activities. According Thai National List Essential Medicines, T. leaves are used for treatment fever. This work sought optimize microwave-assisted drying leaf granules shorten granule process by 32 full factorial design. Power was varied from 300, 450 600 W 5, 10 15 min, minimize moisture content maximize rosmarinic acid content. Results showed optimal condition within design space control power 13 min. gave 4.77 ± 0.24 % 0.0566 0.0075 %. The HPLC method validated; it good linearity, specificity, precision, accuracy. Furthermore, system suitability achieved. obtained were further prepare tablets wet granulation method. Three batches 650 mg containing 250 powder prepared using different compression forces: 500, 1,000 1,500 psi. suitable force psi; tablet formulation had hardness (9.88 0.52 kP), low friability (0.20 %), short disintegration time (23.17 0.76 s). Rosmarinic marker dissolved approximately 75 4 h when 0.5 sodium lauryl sulfate aqueous solution as dissolution medium. In conclusion, could be applied in preparing shortening time. HIGHLIGHTS providing with high min hardness, friability, time, percentage GRAPHICAL ABSTRACT